Interview with K.C. Brennan, MD
Assistant Professor and Division Chief for Translational Neuroscience in the Departments of Neurology, Neurobiology, and Anatomy at the University of Utah
Non-canonical glutamate signaling in a genetic model of migraine with aura
Key Point: What we discovered totally unexpectedly were these plumes or puffs or clouds of glutamate that were released apparently spontaneously in an animal model of migraine. These were animals carrying a gene for migraine that’s transmitted in an Italian family. So this form of glutamate release that we identified was completely unknown and, to our knowledge, hasn’t been reported before, and it does not conform to the rules of canonical glutamate signaling.